姓名：赵龙
职称：讲师
电子邮箱：zhaolong@ntu.edu.cn
个人简介：
赵龙，男，陕西宝鸡市人。2012年本科毕业于兰州大学生命科学学院生物科学国家基地班, 获理学学士学位。2020年于兰州大学基础医学院生物化学与分子生物学专业, 获理学博士学位，导师王锐院士。2020年9月入职南通大学从事教学科研工作。
科研经历：研究生期间，在甘肃省新药临床前重点实验室王锐院士团队，从事非天然氨基酸修饰的神经肽类药物设计和合成、构-效关系、及药理学活性研究相关课题。入职南通大学以来，在医学院陈罡教授团队，以免疫检查点程序性细胞死亡蛋白1（pd-1）为靶点，构建一系列全新镇痛（抗抑郁）类小分子多肽，以期筛选出具有临床应用前景的先导化合物，用于多肽新药的研发。
专业研究领域：慢性疼痛及情绪障碍、镇痛（抗抑郁）类多肽药物
发表论文（按年度）：
1. zhao l, ma y, song xf, wu yj, jin pj, and chen g*. pd-1: a new candidate target for analgesic peptide design.j pain. 2023, 24(7):1142-1150. (if2022 = 4.0)
2. zhang yh1, sang r1, bao jy1, jiang zh, qian dn, zhou y, su wf, wei jh, zhao l, wei zy, zhao yy, shi mx, and chen g*. schwann cell-derived cxcl2 contributes to cancer pain by modulating macrophage infiltration in a mouse breast cancer model.brain behav immun. 2023, 109:308-320. (if2022 = 15.1)
3. zhao l1, luo h1, ma y, zhu sz, wu yj, lu mx, yao xj, liu x, and chen gang*. an analgesic peptide h-20 attenuates chronic pain via the pd-1 pathway with few adverse effects. proceedings of the national academy of sciences. 2022, 119(31)e2204114119.
4.yang ry1, zhao l1, bao jy, wu yj, xia ph, pan jy*.downregulation of nck1 after spinal cord injury in adult rats.balkan med j. 2022, 39(1):39-47. (if2022 = 3.0)
5.zhou jj, zhao l, wei s, wang y*, zhang xh, ma mt, wang kr, liu x*, and wang r*. contribution of the μ opioid receptor and enkephalin to the antinociceptive actions of endomorphin-1 analogs with unnatural amino acid modifications in the spinal cord.peptides. 2021, 141:170543. (if2022 = 3.0)
6. ma mt, wang zj, wang j, wei s, cui jm, wang y, luo ky, zhao l, xin liu, and rui wang*. endomorphin analog exhibited superiority in alleviating neuropathic hyperalgesia via weak activation of nmda receptors.j neurochem. 2020, 155(6):662-678. (if2022 = 4.7)
7. zhaol, luo ky, wang zj, wang y*, zhang xh, yang dx, ma mt, zhou jj, cui jm, wang j, han czy, liu x*, and wang r*.design, synthesis, and biological activity of new endomorphin analogs with multi-site modifications.bioorg med chem. 2020, 28(9):115438. (if2022 = 3.5)
8.cui jm, zhao l, wang zj, ma mt, wang y, luo ky, wang lq, wei s, zhang xh, han czy, liu x*, and wang r*. mel endomorphins act as potent inflammatory analgesics with the inhibition of activated non-neuronal cells and modulation of pro-inflammatory cytokines.neuropharmacology. 2020, 168:107992. (if2022 =4.7)
9.wang c, guo mz, qi rp, shang qy, liu q, wang s, zhao l, wang r*, and xu zq*. visible-light-driven, copper-catalyzed decarboxylative c(sp3)-h alkylation of glycine and peptides.angew chem int ed engl. 2018, 57(48):15841-15846. (if2022 =16.6)
10. liu x, zhao l, wang y, zhou jj, wang d, zhang yx, zhang xh, wang zj, yang dx, mou ly, and wang r*. mel-n16: a series of novel endomorphin analogs with good analgesic activity and a favorable side effect profile.acs chem neurosci. 2017, 8(10):2180-2193. (if2022 =5.0)
11.wang y, yang jx, liu x,zhao l, yang dx, zhou jj, wang d, mou ly, and wang r*. endomorphin-1 analogs containing α-methyl-β-amino acids exhibit potent analgesic activity after peripheral administration.org biomol chem. 2017, 15(23):4951-4955. (if2022 =3.2)
12. wang y, zhou jj, liu x, zhao l, wang zj, zhang xh, wang kz, wang lq, and wang r*. structure-constrained endomorphin analogs display differential antinociceptive mechanisms in mice after spinal administration.peptides. 2017, 91:40-48. (if2022 =3.0)
13. liu x, zhao l, wang y, mou ly, zhang yx, zhou jj, and wang r*. design and synthesis of a novel series of opioid dipeptides and evaluation of their analgesic effect in vivo. acta chim. sinica. 2016, 74:44-48. (if2022 =2.5)
14.liu xh, zhang jl, zhao l, ma sx, yang dx, yan wj, and wang r*. construction of vicinal tetrasubstituted stereocenters with a c-f bond through a catalytic enantioselective detrifluoroacetylative mannich reaction.j org chem. 2015, 80(24):12651-8. (if2022 =3.6)
15.liu x, zhao l, wang y, mou ly, yang jx, zhang yx, wang d, and wang r*. design, synthesis, and evaluation of new endomorphin analogs with enhanced central antinociception after peripheral administration.bioorg med chem lett. 2015, 25(22):5393-7. (if2022 =2.7)
16.wang y, liu x, wang d, yang jx, zhao l, yu j, and wang r*.endomorphin-1 analogues (mels) penetrate the blood-brain barrier and exhibit good analgesic effects with minimal side effects.neuropharmacology. 2015, 97:312-21. (if2022 =4.7)
17. sun qt, li xy, su jh, zhao l, ma mx, zhu yy, zhao yy, zhu rr, yan wj*, wang kr* and wang r*. the squaramide-catalyzed 1, 3 -dipolar cycloaddition of nitroalkenes with n - 2, 2, 2- trifluoroethylisatin ketimines: an approach for the synthesis of 5’-trifluoromethyl-spiro [pyrrolidin-3, 2’-oxindoles]. adv. synth. catal.2015;357:3187-3196. (if2022 =5.4)
18. ma mx, zhu yy, sun qt, li xy, su jh, zhao l, zhao yy, qiu s, yan wj*, wang kr*, and wang r*. the asymmetric synthesis of cf3-containing spiro[pyrrolidin-3,2'-oxindole] through the organocatalytic 1,3-dipolar cycloaddition reaction.chem commun (camb). 2015, 51(42):8789-92. (if2022 =4.9)
19.wang d, liang jy, feng jc, wang kr, sun qt, zhao l, li d, yan wj, and wang r*. the quinine thiourea-catalyzed asymmetric strecker reaction: an approach for the synthesis of 3-aminooxindoles. adv. synth. catal.2013, 355:548-558. (if2022 =5.4)
专利成果（按年度）：
1. 赵龙，陈罡，包璟崟，潘静莹；“一种具有镇痛活性的pd-1靶向肽、其合成方法及其应用”，zl202110451639.1，授权日期：2022年07月05日；
2. 陈罡，赵龙，罗浩，杨日云，陆沐幸；“一类以pd-1受体为靶点的多肽化合物、其制备方法及应用”，国家发明专利，授权专利号：zl202110651404.7，授权日期：2022年06月03日；
3. 王锐，王媛，刘鑫，赵龙；“多位点组合修饰的内吗啡肽类似物及其合成和应用”，国家发明专利，授权专利号：zl201710067056.2，授权日期：2020年08月11日；
4. 王锐，刘鑫，赵龙，王媛；“一类双功能d-氨基酸修饰阿片肽类化合物及其合成方法与应用”，国家发明专利，专利申请号：cn201911188458.3，申请日期：2019年11月28日；
科研项目
1.主持的自然科学基金项目：
(1) 国家自然科学基金委青年科学基金项目(82101302), 靶向pd-1的小分子镇痛肽构建及活性研究, 2022.01.01-2024.12.31
(2)南通市基础科学研究计划 (jc2021113), 具有临床应用前景的pd-1靶向肽化学构建及活性研究，2021.06.01- 2023.06.01
2.参加的自然科学基金项目：
(1)国家自然科学基金委面上项目(32271054)，脊髓ng2细胞tlr2蛋白在神经病理性疼痛中的作用和机制研究, 2023.01.01-2026.12.31
(2) 国家自然科学基金委面上项目(81773566), 一种新型伤口愈合肽的设计及其在糖尿病足治疗中的应用研究, 2018.01.01-2021.12.31
讲授课程
医学细胞生物学、神经科学、神经生物学
