姓名：张小宁
职称：副教授
个人简介：甘肃陇南人，理学博士。
专业研究领域：基础医学、生殖生物学、钙信号及lncrna与雄性不育研究
专著与论集：
1. jian song, xuhui zeng, xiaoning zhang*, yanwei sha* and xiuling zhao*. novel nlrp14 mutations induce azoospermia. andrologia. 2023
2. ai-wen kang, chi sun, hai-tao li, kun zhong, xu-hui zeng, zhi-feng gu, bing-qian li, xiao-ning zhang*, jian-lin gao*, tian-xing chen*. puerarin extends the lifespan of drosophila melanogaster by activating autophagy. food funct. 2023 feb 21;14(4):2149-2161.
3. shijue dong, chen chen, jiali zhang, yuan gao, xuhui zeng*, xiaoning zhang*. testicular aging, male fertility and beyond. front endocrinol (lausanne). 2022 oct 13;13:1012119.
4. yang zhou#, shijue dong#, chen chen, xiaojun liu, xuhui zeng, yuan gao*, xiaoning zhang*. lncrna 1700101o22rik and nonmmug030480.1 are not essential for spermatogenesis in mice. int j mol sci. 2022 aug 3;23(15):8627.
5. hui lin#, peng xiao#, rui-qian bu#, shengchao guo#, zhao yang#, daopeng yuan#, zhong-liang zhu, chuan-xin zhang, qing-tao he, chao zhang, yu-qi ping, ru-jia zhao, chuan-shun ma, chang-hao liu, xiao-ning zhang, dan jiang, shaohui huang, yue-tong xi, dao-lai zhang, chen-yang xue, bai-sheng yang, jian-yuan li, hao-cheng lin, xu-hui zeng, han zhao，wen-ming xu, fan yi*, zhongmin liu*, jin-peng sun*, xiao yu*. structures of the adgrg2-gs complex in apo and ligand-bound forms. nat chem biol. 2022 nov;18(11):1196-1203.
6. chen chen#, bingqian li#, rongzu huang, shijue dong, yang zhou, jian song, xuhui zeng* and xiaoning zhang*. involvement of ca2 and ros signals in nickel-impaired human sperm function. ecotoxicol. environ. saf. 2022 jan; 231 (2022) 113181.
7. hang kang, chen chen, fengxin gao, xuhui zeng, xiaoning zhang*. expression of ppp3cc and not ppp3r2 is associated with asthenozoospermia. j. mens health. 2021 sep; 17(4):183-189.
8. yang zhou#, xiaona zhang#, suping xiong, xuhui zeng*, xiaoning zhang*. predicted gene 31453 (gm31453) and the gene encoding carboxypeptidase a5 (cpa5) are not essential for spermatogenesis and male fertility in the mouse. reprod. fertil. dev.2021 apr;33(6):401-409.
9. xiaoning zhang, wenwen zhou, peng zhang, fengxin gao, xiuling zhao, winnie waichi shum* and xuhui zeng*. cabs1 maintains structural integrity of mouse sperm flagella during epididymal transit of sperm.int. j. mol. sci. 2021 jan 11;22(2):e652.
10. xiaoning zhang*, rongzu huang, yang zhou, wenwen zhou and xuhui zeng*. ip3r channels in male reproduction. int. j. mol. sci.2020 dec 2;21(23):9179.
11. xiaoning zhang, chen chen, yuanyuan zhong, xuhui zeng*. lncrna involved in triptonide-induced cytotoxicity in mouse germ cells. reprod. toxicol. 2020 dec;98:218-224.
12. xiaoning zhang, hang kang, lizhong peng, dandan song, xin jiang, yanting li, houyang chen, xuhui zeng*. pentachlorophenol inhibits catsper function to compromise progesterone’s action on human sperm. chemosphere. 2020 nov;259:127493.
13. yangyang yuan, xinbao ding, yimin cheng, hang kang, tao luo, xiaoning zhang, haibin kuang, ying chen, xuhui zeng*, dalei zhang*. pfoa evokes extracellular ca2 influx and compromises progesterone-induced response in human sperm. chemosphere2020 feb;241:125074.
14. suping xiong, dandan song, yang xiang, yanting li, yuanyuan zhong, hongjin li, peng zhang, wenwen zhou, xuhui zeng, xiaoning zhang*. reactive oxygen species, not ca2 , mediates methotrexate-induced autophagy and apoptosis in spermatocyte cell line. basic clin. pharmacol. toxicol.2020 feb;126(2):144-152.
15. suping xiong, yanting li, yang xiang, na peng, chunmiao shen, yanqiu cai, dandan song, peng zhang, xiaolong wang, xuihui zeng and xiaoning zhang*. dysregulation of lncrna and circrna expression in mouse testes after exposure to triptolide. curr. drug metab.2019;20(8):665-673.
16. xiaoning zhang, peng zhang, dandan song, suping xiong, hongyan zhang, jianbo fu, fengxin gao, houyang chen and xuhui zeng*. expression profiles and characteristics of human lncrna in normal and asthenozoospermia sperm. biol. reprod.2019 apr 1;100(4):982-993.
17. liping zheng, ruichen luo, tie su, liaoliao hu, fengxin gao, and xiaoning zhang*. differentially expressed lncrnas after the activation of primordial follicles in mouse. reproductive sciences. 2019,26:1094-1104.
18. dejun huang*, xiaoning zhang, chen zhang, hui li, dong li, yan hu, feng yang, yongmei qi. 2,4-dichlorophenol induces dna damage through ros accumulation and gsh depletion in goldfish carassius auratus. environ. mol. mutagen.2018 dec;59(9):798-804.
19. xiaoning zhang, fengxin gao, jianbo fu, peng zhang, yuqing wang, xuhui zeng*. systematic identification and characterization of long non-coding rnas in mouse mature sperm. plos one, 2017, 12(3): e0173402.
20. fengxin gao#, peng zhang#, hongyan zhang, yunhui zhang, yunwen zhang, qingyun hao, xiaoning zhang*. dysregulation of long noncoding rnas in mouse testes and spermatozoa after exposure to cadmium. biochem. biophys. res. commun. 2017; 484(2017):8-14.
21. jianbo fu, xiaoning zhang*, peng chen and yingmei zhang. endoplasmic reticulum stress is involved in 2,4-dichlorophenol-induced hepatotoxicity. j toxicolol sci. 2016; 41(6):745-756.
22. zhidan niu, wenya zhang, xueyan gu, xiaoning zhang, yongmei qi, yingmei zhang*. mitophagy inhibits proliferation by decreasing cyclooxygenase-2 (cox-2) in arsenic trioxide-treated hepg2 cells. environ. toxicol. pharmacol. 2016 jul;45:212-21.
23. xiaoning zhang, xiaona zhang, yongmei qi, dejun huang*, yingmei zhang*. 2,4-dichlorophenol induces er stress-mediated apoptosis via eif2α dephosphorylation in vitro. environl toxicol. 2016.31(2):245-255.
24. xue wei, yongmei qi, xiaoning zhang, xueyan gu, hui cai, jing yang, and yingmei zhang*. ros act as an upstream signal to mediate cadmium-induced mitophagy in brain of mouse. neurotoxicology. 2015;46c: 19-24.
25. xue wei, yongmei qi, xiaoning zhang, qian qiu, xueyan gu, chen tao, dejun huang, yingmei zhang. cadmium induces mitophagy through ros-mediated pink1/parkin pathway. toxicol. mech. methods. 2014 oct;24(7):504-11.
26. weiwei li, xueyan gu, xiaoning zhang, jinxin kong, nan ding, yongmei qi, yingmei zhang, jufang wang, dejun huang*. cadmium delays non-homologous end joining(nhej) repair via inhibition of dna-pkcs phosphorylation and downregulation of xrcc4 and ligaseiv. mutat res.2015;779:112-123.
27. xiaoning zhang, xiaona zhang, zhidan niu, yongmei qi, dejun huang*, yingmei zhang*. 2,4,6-trichlorophenol cytotoxicity involves oxidative stress, endoplasmic reticulum stress and apoptosis. int j toxico. 2014;33(6):532-541.
28. xiaoning zhang, hui li, yongmei qi, dejun huang*, yingmei zhang*. 2,4- dichloro -phenol induces global dna hypermethylation through the increase of s-adenosylmethionine and the upregulation of dnmts mrna in the liver of goldfish carassius auratus. comp. biochem. physiol. c toxicol. pharmacol. 2014;160:54-59.
29. hui li, xiaoning zhang, qian qiu, zhen an, yongmei qi, dejun huang*, yingmei zhang*. 2,4-dichlorophenol induces apoptosis in primary hepatocytes of grass carp (ctenopharyngodon idella) through mitochondrial pathway. aquat. toxicol.2013,140-141:117-122.
30. yingxia liu, wenya zhang, xiaoning zhang, yongmei qi, dejun huang, yingmei zhang*. arsenic trioxide inhibits invasion/migration in sgc-7901 cells by activating the reactive oxygen species-dependent cyclooxygenase-2/matrix metalloproteinase-2 pathway. expl. bio. med. 2011; 236: 592-597.
发明专利
1. 一种快速分离精子头、精子尾和正常有活力精子的方法（zl 202010186121.5）
2. 一种利用精浆外泌体改善精子功能的方法（zl 202110280768.9）
3. 一种改善精子功能的含有idgr序列的多肽及其应用（zl 202210210465.4）
主要科研项目
主持完成多项省部级以上科研项目，其中包括国家自然科学基金项目2项。主持在研南通市科技项目1项，参与多项国家及省部级科研项目。
讲授课程
生殖生物学及其进展、细胞信号转导
指导研究生情况
已毕业硕士生1名；在读硕士生3名。联合指导博士生1名，硕士生10人（已毕业7人）。
